MyBioSource.com's DDIT3/CHOP mouse monoclonal Antibody is a Mouse monoclonal antibody. The DDIT3/CHOP mouse monoclonal Antibody was generated using DDIT3 as the antigen. It reacts with Mouse, and Rat. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, and Western Blot.
Description
CHOP was identified as a C/EBP-homologous protein that inhibits C/EBP and LAP in a dominant-negative manner (1). CHOP expression is induced by certain cellular stresses including starvation and the induced CHOP suppresses cell cycle progression from G1 to S phase (2). Later it was shown that, during ER stress, the level of CHOP expression is elevated and CHOP functions to mediate programmed cell death (3). Studies also found that CHOP mediates the activation of GADD34 and Ero1-Lalpha expression during ER stress. GADD34 in turn dephosphorylates phospho-Ser51 of eIF2alpha thereby stimulating protein synthesis. Ero1-Lalpha promotes oxidative stress inside the endoplasmic reticulum (ER) (4). The role of CHOP in the programmed cell death of ER-stressed cells is correlated with its role promoting protein synthesis and oxidative stress inside the ER (4)